Grapefruit and Medications: What You Need to Know Before Your Next Bite
July 14 • 2025
Grapefruit contains a natural compound that interferes with an enzyme in your small intestine called CYP3A4. This enzyme plays a crucial role in breaking down many commonly prescribed medications. Hermanda West, FNP-BC breaks down everything you need to know in the video below.
When grapefruit blocks this enzyme, your body may absorb more of the medication than it should. That can lead to intensified side effects, unwanted reactions, or even toxic levels of the drug in your system.
Common Medications Affected by Grapefruit
If you’re taking any of the following medications, it’s important to check with your healthcare provider before consuming grapefruit or grapefruit juice:
- Cholesterol medications (especially statins like Lipitor or Zocor)
- Blood pressure medications
- Certain anti-anxiety drugs (like Benzodiazepines and Buspirone)
- Allergy medications (particularly antihistamines like Allegra)
These medications rely on the CYP3A4 enzyme to be processed safely in your body. When grapefruit disrupts that process, it increases your risk for serious side effects.
Other Fruits with Similar Effects
In addition to grapefruit some of the following citrus fruits can interfere with medications.
Seville oranges, Limes, Pomelos, and tangelos can cause similar interactions with medications like that of Grapefruit.
What You Should Do
At Aylo Health, our providers take a whole-person approach to your care. That means we look beyond just prescriptions—we consider your diet, lifestyle, and supplements to help you avoid potential interactions and stay on the right path.
If you’re ever unsure about whether a food or supplement might interfere with your medications, don’t guess. Talk to your Aylo Health provider or pharmacist. We’re here to help you make the safest choices for your long-term health.
Experience Better Primary Care This Summer
Whether you’re managing a chronic condition or just need a quick checkup, Aylo Health offers comprehensive, personalized primary care close to home. With multiple convenient locations across Atlanta, including Woodstock, Suwanee, Dawsonville, and Hickory Flat, we make it easy to get the care you deserve.
Schedule your visit today and experience better primary care in Georgia—only at Aylo Health.